363P The TGFβ2/GSK3β/β-catenin axis shapes the aggressive phenotypes of macrotrabecular-massive HCC

Hepatocellular carcinoma (HCC) represents a formidable challenge in oncology, and among its diverse subtypes, Macrotrabecular-hepatocellular carcinoma (MTM-HCC) emerges as a particularly aggressive variant. MTM-HCC constitutes 10-15% of all HCC cases and is associated with dismal prognoses, marked by early recurrence and reduced overall survival. MTM-HCC is notably linked to vascular invasion, advanced tumor stages, HBV infection, and elevated alpha-fetoprotein levels. A unique feature of MTM-HCC is its sinusoid-like microvascular pattern,

Authors

Institutions

Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101360
Primary Topic
TGF-β signaling in diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

363P The TGFβ2/GSK3β/β-catenin axis shapes the aggressive phenotypes of macrotrabecular-massive HCC

W.K. Kim, Y. Kwon, S.Y. Lee, H. Rhee et al.
Immuno-Oncology Technology
TGF-β signaling in diseases
article

363P The TGFβ2/GSK3β/β-catenin axis shapes the aggressive phenotypes of macrotrabecular-massive HCC

W.K. Kim, Y. Kwon, S.Y. Lee, H. Rhee, S-Y. Cho
article en

Abstract

Hepatocellular carcinoma (HCC) represents a formidable challenge in oncology, and among its diverse subtypes, Macrotrabecular-hepatocellular carcinoma (MTM-HCC) emerges as a particularly aggressive variant. MTM-HCC constitutes 10-15% of all HCC cases and is associated with dismal prognoses, marked by early recurrence and reduced overall survival. MTM-HCC is notably linked to vascular invasion, advanced tumor stages, HBV infection, and elevated alpha-fetoprotein levels. A unique feature of MTM-HCC is its sinusoid-like microvascular pattern,

Immuno-Oncology TechnologyVol. 28
Severance Hospital (KR), Gangnam Severance Hospital (KR), Korea Institute of Science and Technology (KR), Korea University of Science and Technology (KR)
Good health and well-being
Openalex Percentile: Top 36%
TGF-β signaling in diseases
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

363P The TGFβ2/GSK3β/β-catenin axis shapes the aggressive phenotypes of macrotrabecular-massive HCC — W.K. Kim, Y. Kwon, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS