Associations Between Systemic Inflammatory Markers, Metabolic Dysfunction, and Liver Fibrosis Scores in Patients with MASLD
This study reveals a dissociation between systemic inflammatory markers and hepatic fibrosis severity in MASLD. Inflammatory Markers showed stronger metabolic associations than fibrosis, limiting their utility as fibrosis surrogates in early MASLD. These findings support a dual-pathway approach to MASLD management, targeting metabolic and hepatic components independently. The divergent associations of TNF-α and hsCRP with lipid profiles suggest distinct inflammatory mechanisms in MASLD.
Authors
- A. Sulthan Ibrahim
- Hoda Rabea (ORCID: https://orcid.org/0000-0003-0432-8970)
- Engy A. Wahsh (ORCID: https://orcid.org/0000-0001-6359-5011)
- Sara O. Elgendy (ORCID: https://orcid.org/0000-0002-1360-5493)
- Shaymaa Nafady (ORCID: https://orcid.org/0000-0002-8207-2934)
- Yasmin M. Madney (ORCID: https://orcid.org/0000-0003-4105-7874)
- Ahmed M. Abdel Hamied (ORCID: https://orcid.org/0000-0002-4507-5570)
- Ahmed Hamed Fatehy (ORCID: https://orcid.org/0000-0002-1078-7260)
- Khalid Mubarak Orayj (ORCID: https://orcid.org/0000-0001-6651-2306)
- Ragaey Ahmad Eid
- Maha Youssif
- Dina Attia
Institutions
- Beni-Suef University (EG)
- Nahda University (EG)
- October 6 University (EG)
- King Khalid University (SA)
Publication Details
- Journal
- Metabolites
- Published
- 2025-12-25
- DOI
- https://doi.org/10.3390/metabo16010025
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- King Khalid University