Intravitreal aflibercept 8 mg in patients from Japan with diabetic macular edema: 48-week subgroup analysis of the PHOTON trial
Improvements in BCVA at Week 48 were generally similar with aflibercept 8 mg versus 2 mg in this subgroup analysis of Japanese and non-Japanese patients with DME, suggesting that the primary findings from PHOTON may be generalized to the Japanese population.
Authors
- Wilfredo Lara
- András Seres (ORCID: https://orcid.org/0000-0001-8260-3566)
- Justin Parschauer
- Hani Salehi-Had (ORCID: https://orcid.org/0000-0003-2631-7754)
- Masahiko Shimura (ORCID: https://orcid.org/0000-0001-5456-6374)
- Veeral Sheth (ORCID: https://orcid.org/0000-0002-7467-9947)
- Christopher A. Devine
- Paul Conrad
- Lawrence J. Singerman (ORCID: https://orcid.org/0000-0002-9048-8358)
- Yasuko Ikegami (ORCID: https://orcid.org/0000-0002-1704-585X)
- Dana Madison Deupree
- AMR DESSOUKI
- Jamin S. Brown
- Adam T. Gerstenblith
- Hiroaki Ushida (ORCID: https://orcid.org/0000-0001-6550-075X)
- Nicolas Feltgen (ORCID: https://orcid.org/0000-0002-6857-3003)
- Calvin E. Mein (ORCID: https://orcid.org/0000-0001-9316-0596)
- Hajir Dadgostar
- Rafia Bhore
- Jordana Fein (ORCID: https://orcid.org/0000-0001-7198-3823)
- Liliya Golas
- Vrinda Hershberger (ORCID: https://orcid.org/0000-0001-8677-8582)
- Kunihiko Akiyama
- Ashkan Pirouz
- Jeffrey J. Tan (ORCID: https://orcid.org/0000-0001-9939-9506)
- Peter H. Win
- Julie Gasperini
- Jeffrey S. Heier (ORCID: https://orcid.org/0000-0003-4625-3145)
- Masato Kobayashi (ORCID: https://orcid.org/0000-0001-7717-8948)
- Sumit P. Shah
- Sunir Joshi
- Omar S. Punjabi
- Akira Hagiwara
- Matthew Pezda
- Yoshihiro Yonekawa (ORCID: https://orcid.org/0000-0002-6847-7169)
- Shigeru I. Honda (ORCID: https://orcid.org/0000-0002-0632-997X)
- Ramin Schadlu
- Balázs Varsányi (ORCID: https://orcid.org/0000-0002-3891-3839)
- Delia Voronca
- Namie Kobayashi
- Mitchell J. Goff
- Fareed Ali
- Peter Morgan-Warren
- Genichiro Kishino
- Vladimír Korda
- M. J. Fenberg
- Kazuhiro Kimura (ORCID: https://orcid.org/0000-0002-2502-6149)
- Michel Giunta
- Katalin Kiss (ORCID: https://orcid.org/0000-0003-4599-067X)
- James M. Osher
- Robert Vitti
- Ágnes Kerényi (ORCID: https://orcid.org/0009-0007-0275-0402)
- Hajime Onoe
- Atul Jain (ORCID: https://orcid.org/0000-0002-6946-5020)
- Isao Ishikawa (ORCID: https://orcid.org/0000-0002-3100-6187)
- Ursula Schmidt-Ott
- Andrea Schulze
- Erik Kruger
- Alyson J. Berliner
- Yoshio Hirano (ORCID: https://orcid.org/0000-0002-9173-0839)
- Adam Berger (ORCID: https://orcid.org/0000-0002-1302-4007)
- Shigeo Yoshida (ORCID: https://orcid.org/0000-0003-1049-8909)
- Joseph M. Googe
- Kimberly Reed
- Ramanath Bhandari (ORCID: https://orcid.org/0000-0003-1155-4693)
- Dennis M. Marcus (ORCID: https://orcid.org/0000-0002-5065-6716)
- Sobha Sivaprasad
- Yenchieh Cheng
- Toshinori Murata (ORCID: https://orcid.org/0000-0001-6577-5032)
- Jorge I. Calzada
- Vivienne Hau
- Eric Jablon
- Yoshinori Mitamura (ORCID: https://orcid.org/0000-0001-9598-7765)
- Jason M. Handza
- Andres Emanuelli Anzalotta
- Dana Cervena
- Milan Shah (ORCID: https://orcid.org/0000-0002-3572-7408)
- Yuichiro Ishida (ORCID: https://orcid.org/0000-0002-6690-8463)
- James K. Luu
- Jan Ernest
- Deepali Varma
- Curtis Hagedorn
- Kapil Kapoor (ORCID: https://orcid.org/0000-0001-5622-225X)
- Raymond Wee
- Richard H. Roe
- Kiyoshi Ishii (ORCID: https://orcid.org/0000-0001-7117-3361)
- Scott M. Friedman
- James M. Klancnik
- Nauman Chaudhry
- Annal D. Meleth (ORCID: https://orcid.org/0000-0002-6650-9999)
- R. E. P. Frenkel
- Georg Spital
- Attila Vajas
- Sandeep N. Shah (ORCID: https://orcid.org/0000-0001-9076-6162)
- Yuichi Kaji
- Llewelyn Rao
- György Bátor
- Patrick Higgins
- Aderman
- Prema Abraham
- W. Lloyd Clark
- András Papp
- Taiji Sakamoto
- Matthew Cunningham
- Ashish Sharma
- Christopher
- Sentaro Kusuhara
- William Bridges
- Tibor Milibák
- David M. Brown
- Diana Do
- Eric Suan
- Daniel V. Alfaro
- Karen W. Chu
- Ken Hayashi
- Haruhiko Yamada
- David Chow
- Masaru Takeuchi
- the PHOTON Investigators
- Ghassan Ghorayeb
- Sumiyo Noge
- Geoff Williams
- Pamela Weber
- Antonio Capone
- Charles Wykoff
- Christian Brinkmann
- Payam Amini
- Seong Lee
- Philip Ferrone
- Kiyoshi Suzuma
- Steven Charles
- Sergio Leal
- Benjamin Thomas
- Tetsuo Ueda
- Robert Stoltz
- Eric Schneider
- Paul Hahn
- Jiro Kogo
- Stuart Burgess
- Pradeep Prasad
- Sunil Patel
- Takashi Kitaoka
- Richard Hairston
- Hidenori Takahashi
- Yoshihiro Takamura
- Miroslav Veith
- Ankur Shah
- Ketan Laud
- Edit Tóth-Molnár
- Sugat Patel
- David Eichenbaum
Institutions
- Kurume University (JP)
- Kagoshima University (JP)
- Regeneron (United States) (US)
- Tokyo Medical University Hachioji Medical Center (JP)
- Bayer (Switzerland) (CH)
- Shinshu University Hospital (JP)
- Kagawa University Hospital (JP)
- Aizawa Hospital (JP)
- Bayer (Japan) (JP)
- Bayer (Germany) (DE)
Publication Details
- Journal
- Japanese Journal of Ophthalmology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1007/s10384-025-01271-7
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00