Characterizing patients with early onset Alzheimer's Disease and amyloid‐positive, tau‐negative (A+T‐) PET profiles: data from the longitudinal Early‐Onset Alzheimer's Disease Study (LEADS)
In amyloid-positive patients with EOAD, tau-PET results were predominantly positive regardless of tau-status definitions (93-97%). The rare A+T- profile may reflect early disease stages, with tau pathology below PET detection levels.
Authors
- Konstantinos Chiotis (ORCID: https://orcid.org/0000-0002-5679-0297)
- J. Zhang (ORCID: https://orcid.org/0000-0003-2572-2555)
- Ranjani Shankar
- Claire Yballa
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Salma Rocha
- Ehud Zeltzer (ORCID: https://orcid.org/0000-0002-1146-0358)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Ganna Blazhenets (ORCID: https://orcid.org/0000-0003-2419-7373)
- Charles Windon (ORCID: https://orcid.org/0000-0001-8719-1206)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Alinda Amuiri
- David Soleimani‐Meigooni
- Piyush Maiti
- Brad C. Dickerson
- Agathe Vrillon
- Maison Abu Raya
- Liana G. Apostolova
- Robert A. Koeppe
- Maria C. Carrillo
- Julien Lagarde
- Gil D. Rabinovici
Institutions
- Alzheimer's Association (US)
- Harvard University (US)
- Lawrence Berkeley National Laboratory (US)
- University of California, San Francisco (US)
- Brown University (US)
- University of Michigan (US)
- University of California System (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Centre Hospitalier Sainte-Anne (FR)
- FHU Neurovasc (FR)
- Global Brain Health Institute (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103476
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00