Clinical associations of CSF TMEM106B in familial and sporadic frontotemporal lobar degeneration
CSF TMEM106B concentrations are influenced by the TMEM106B rs1990622 genotype, and correlate with disease severity and brain volume in both genetic and sporadic FTLD. Lower levels of CSF TMEM106B correlate with more severe disease and brain atrophy. Disease severity is more strongly associated with CSF NfL, while brain volumes are more strongly associated with CSF TMEM106B. CSF TMEM106B may have value as a biomarker of neurodegeneration in FTLD.
Authors
- Lawren VandeVrede (ORCID: https://orcid.org/0000-0002-8304-6711)
- Mark Sanderson‐Cimino (ORCID: https://orcid.org/0000-0002-5872-3186)
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Peter Alexander Ljubenkov (ORCID: https://orcid.org/0000-0002-3348-9215)
- Joseph Loureiro (ORCID: https://orcid.org/0000-0001-7222-9160)
- Casey Cook (ORCID: https://orcid.org/0000-0002-5963-8442)
- Yann Cobigo (ORCID: https://orcid.org/0000-0002-0354-4092)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-5730-5388)
- Binita Rajbanshi
- Argentina Lario Lago
- Julia D Webb
- Eden V. Barragan
- Molly Olzinski
- Brad F Boeve
- Jingyao Li
- Howard J. Rosen
- Rosa Rademakers
- Eliana Marisa Ramos
- Adam L. Boxer
- Leonard Petrucelli
- Rowan Saloner
- Katie Worringer
Institutions
- University of Antwerp (BE)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- WinnMed (US)
- University Memory and Aging Center (US)
- Novartis (United States) (US)
- Mayo Clinic in Arizona (US)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103985
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00