Increased cortical mean diffusivity in cognitively unimpaired individuals with elevated plasma ptau217
In our study of a large-scale, well-characterised cognitively unimpaired population with available diffusion weighted imaging, changes in cortical MD can already be observed in those with elevated plasma ptau217 in regions commonly associated with AD neuropathology. Further analysis on longitudinal MD changes in the same cohort are ongoing.
Authors
- Michel J. Grothe (ORCID: https://orcid.org/0000-0003-2600-9022)
- Eva Alfayate (ORCID: https://orcid.org/0000-0003-4673-9882)
- Pascual Sánchez‐Juan (ORCID: https://orcid.org/0000-0002-6081-8037)
- Linda Zhang (ORCID: https://orcid.org/0000-0003-2122-9771)
- Jesús Silva‐Rodríguez
- Sonia Wagner
Institutions
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104410
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00