Reference charts of plasma p‐tau217 as a pre‐screening tool in AD clinical trials
Our study demonstrates that plasma p-tau217 is an effective pre-screening tool for clinical trials, with the intermediate threshold being the most cost-effective for both CU and CI. This approach reduces the need for Aβ-PET scans and optimizes recruitment time and costs, potentially enhancing the efficiency of clinical trial designs within the AD spectrum.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Hyun Woong Roh (ORCID: https://orcid.org/0000-0002-1333-358X)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Helmet T. Karim (ORCID: https://orcid.org/0000-0002-9286-0694)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Chang Hyung Hong (ORCID: https://orcid.org/0000-0003-3258-7611)
- Sang Joon Son (ORCID: https://orcid.org/0000-0001-7434-7996)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Pamela C.L. Ferreira
- Guilherme Povala
- Carolina Soares
- João Pedro Ferrari‐Souza
- Eduardo R. Zimmer
- Ann D Cohen
- Marina Scop Madeiros
- Thomas K Karikari
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- Instituto do Cérebro (BR)
- McGill University (CA)
- Ajou University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_105750
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00