THE ROLE OF ORAL SUPPLEMENTS IN MITIGATING COMMON ISOTRETINOIN SIDE EFFECTS: A COMPREHENSIVE REVIEW

Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 9% of the global population. This condition arises from the multifactorial interplay of genetic predisposition, hormonal imbalances, excessive sebum production, hyperkeratinization of follicular infundibula, and proliferation of Cutibacterium acnes, culminating in inflammation and comedone formation. While various therapeutic modalities exist, including topical retinoids, antibiotics, and hormonal agents, oral isotretinoin remains one of the most efficacious treatments for acne vulgaris. Notwithstanding its superior effectiveness, the drug is associated with a spectrum of adverse effects that warrant mitigation strategies. The primary aim of this narrative review is to evaluate the efficacy and rationale for employing oral supplements to alleviate the most prevalent isotretinoin-related side effects. By synthesizing extant research, this study appraises the benefits and limitations of select supplement interventions. The central clinical question addressed is: What is the role of oral supplements in mitigating common adverse effects among patients receiving isotretinoin therapy? Findings are expected to furnish clinicians and patients with evidence-based guidance on adjunctive supplement use to enhance treatment tolerability.