TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters

The TMEM106B-rs1990622 protective variant significantly modulates disease progression in genetic FTD phenoconverters across multiple markers, suggesting its potential as a therapeutic target.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103532
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters

Alexander Gerhard, Matthis Synofzik, Johannes Levin, Alexandre de Mendonça et al.
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters

Alexander Gerhard, Matthis Synofzik, Johannes Levin, Alexandre de Mendonça, David M. Cash, Andrew D. Paterson, Martina Bocchetta, Maurice Pasternak, Markus Otto, Elizabeth C. Finger, Judith S. Rowe, Caroline Graff, Barbara Borroni, Carmela M. Tartaglia, Ekaterina Rogaeva, Fabrizio Tagliavini, Mario Masellis, Sara Berman Mitchell, Simon Ducharme, David F. Tang‐Wai, Saira S. Mirza, Fermin Moreno, Isabel Santana, GENFI, Morris Freedman, Daniela Galimberti, John van Swieten, Rik Vandenberghe, Robert Laforce, Christopher Butler, Sandro Sorbi, Jonathan D. Rohrer, Sandra E. Black, Raquel Sánchez‐Valle
article en

Abstract

The TMEM106B-rs1990622 protective variant significantly modulates disease progression in genetic FTD phenoconverters across multiple markers, suggesting its potential as a therapeutic target.

Alzheimer s & DementiaVol. 21(S2)
Western University (CA), Montreal Neurological Institute and Hospital (CA), Sunnybrook Health Science Centre (CA), University Health Network (CA), Karolinska University Hospital (SE), University of Lisbon (PT), University of Toronto (CA), University of Milan (IT), MRC Cognition and Brain Sciences Unit (GB), University of Cambridge (GB), Toronto Western Hospital (CA), Douglas Mental Health University Institute (CA), Universitair Ziekenhuis Leuven (BE), Hospital for Sick Children (CA), German Center for Neurodegenerative Diseases (DE), Erasmus MC (NL), Health Sciences Centre (CA), Baycrest Hospital (CA), Cambridge University Hospitals NHS Foundation Trust (GB), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Karolinska Institutet (SE), University of Manchester (GB), University of Oxford (GB), Biogipuzkoa Health Research Institute (ES), Occupational Cancer Research Centre (CA), Munich Cluster for Systems Neurology (DE), Hospital Clínic de Barcelona (ES), Don Carlo Gnocchi Foundation (IT), UK Dementia Research Institute (GB), Klinikum Arnsberg (DE), NIHR Queen Square Dementia Biomedical Research Unit (GB), Hertie Institute for Clinical Brain Research (DE), National Hospital for Neurology and Neurosurgery (GB), VIB-KU Leuven Center for Brain & Disease Research (BE), University Hospital Ulm (DE), Ontario Brain Institute (CA), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT), Université Laval (CA), Sunnybrook Research Institute, University of Florence (IT), University College London (GB), Imperial College London (GB), McGill University (CA), University of Coimbra (PT), University of Brescia (IT), University of Tübingen (DE), Ludwig-Maximilians-Universität München (DE), Medical Research Council (GB)
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Amyotrophic Lateral Sclerosis Research
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