TMEM106B modulates disease severity in genetic frontotemporal dementia phenoconverters
The TMEM106B-rs1990622 protective variant significantly modulates disease progression in genetic FTD phenoconverters across multiple markers, suggesting its potential as a therapeutic target.
Authors
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Andrew D. Paterson (ORCID: https://orcid.org/0000-0002-9169-118X)
- Martina Bocchetta (ORCID: https://orcid.org/0000-0003-1814-5024)
- Maurice Pasternak (ORCID: https://orcid.org/0000-0003-0647-172X)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Elizabeth C. Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Judith S. Rowe
- Caroline Graff
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Carmela M. Tartaglia
- Ekaterina Rogaeva
- Fabrizio Tagliavini
- Mario Masellis
- Sara Berman Mitchell
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- David F. Tang‐Wai
- Saira S. Mirza
- Fermin Moreno
- Isabel Santana
- GENFI
- Morris Freedman
- Daniela Galimberti
- John van Swieten
- Rik Vandenberghe
- Robert Laforce
- Christopher Butler
- Sandro Sorbi
- Jonathan D. Rohrer
- Sandra E. Black
- Raquel Sánchez‐Valle
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Karolinska University Hospital (SE)
- University of Lisbon (PT)
- University of Toronto (CA)
- University of Milan (IT)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Toronto Western Hospital (CA)
- Douglas Mental Health University Institute (CA)
- Universitair Ziekenhuis Leuven (BE)
- Hospital for Sick Children (CA)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- Health Sciences Centre (CA)
- Baycrest Hospital (CA)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University of Oxford (GB)
- Biogipuzkoa Health Research Institute (ES)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Hospital Clínic de Barcelona (ES)
- Don Carlo Gnocchi Foundation (IT)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University Hospital Ulm (DE)
- Ontario Brain Institute (CA)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- Sunnybrook Research Institute
- University of Florence (IT)
- University College London (GB)
- Imperial College London (GB)
- McGill University (CA)
- University of Coimbra (PT)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Medical Research Council (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103532
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00