Utilizing Memory Recall Response Time on Digital Cognitive Testing to Detect Subtle Cognitive Changes Associated with Preclinical Alzheimer's Disease
Even among correct responses, recall speed-a novel and underexplored metric-revealed critical insights: RT tracks memory consolidation and functions as a pathology-specific marker, complementing traditional accuracy measures susceptible to ceiling effects in individuals without overt cognitive decline. Furthermore, we found that tau burden concurrently affects RT alongside age effect, with pronounced effects in individuals under 74-highlighting its potential to detect early Alzheimer's disease pathology.
Authors
- Mark A. Dubbelman (ORCID: https://orcid.org/0000-0002-5708-4925)
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Daniel Soberanes (ORCID: https://orcid.org/0000-0001-9099-7294)
- Gad Marshall
- Onyinye J. Udeogu
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Lia D'Aquila
- Hairin Kim
- Keith A. Johnson
- Dorene M. Rentz
- Reisa A. Sperling
- Kathryn V Papp
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104903
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00