Automated pause analysis of connected speech from story recall as markers of cognitive decline
Participants with MCI produced shorter SR samples with a larger percentage and duration of pauses than CU participants. Shorter speech duration correlated with higher amyloid-beta levels. This contrasts with the longer CT speech duration in the MCI group, possibly due to SR's episodic memory demands. Automated, acoustic-based pause analysis shows promise as an early AD marker, warranting further study in larger, diverse cohorts.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Visar Berisha (ORCID: https://orcid.org/0000-0001-8804-8874)
- Deling He (ORCID: https://orcid.org/0000-0003-4690-6871)
- Kristin E Basche (ORCID: https://orcid.org/0000-0001-5767-8507)
- Julie Liss (ORCID: https://orcid.org/0000-0001-8782-2901)
- Kimberly D. Mueller (ORCID: https://orcid.org/0000-0001-8691-9517)
- Lingfeng Xu
- Madeline R Hale
- Rebecca E. Langhough
- Bruce P Hermann
Institutions
- University of Wisconsin–Madison (US)
- Geriatric Research Education and Clinical Center (US)
- University of Wisconsin Health (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Wisconsin Division of Public Health (US)
- Arizona State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103818
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00