Precision Modeling of Alzheimer’s Disease via Integrative Pathway Activity Analysis across Human Brains and Cellular Models for Discovering Translatable Therapeutic Targets
IPAA enables rapid preclinical assessment of target pathways with confidence for impact on AD pathology prior to clinical trials. Our findings highlight the critical role of protein kinase networks, particularly the p38 MAPK-MK2 axis, in driving AD pathology in humans.
Authors
- Doo Yeon Kim (ORCID: https://orcid.org/0000-0002-6969-0340)
- Sang Su Kwak (ORCID: https://orcid.org/0000-0001-8210-6738)
- Mehdi Jorfi (ORCID: https://orcid.org/0000-0003-4724-6190)
- Weiming Xia
- Pourya Naderi Yeganeh
- Winston Hide
- Rudolph E. Tanzi
Institutions
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_106163
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00