Associations between cerebral blood transit time, amyloid‐β pathology and cognitive decline in non‐demented older adults
Vascular risks are associated with prolonged arterial transit time (Lag<sub>ICA-global</sub>) and cerebral blood transit time (Lag<sub>ICA-SSS</sub>). Prolonged venous blood transit time (Lag<sub>global-SSS</sub>) and Lag<sub>ICA-SSS</sub> are linked to accelerated Aβ accumulation. Aβ burden mediates the association between prolonged Lag<sub>ICA-global</sub> and Lag<sub>ICA-SSS</sub> and cognitive impairment. Aβ Amyloid burden may interact synergistically with prolonged Lag<sub>ICA-global</sub> and Lag<sub>global-SSS</sub> to exacerbate cognitive decline.
Authors
- L. Liu
- Kaicheng Li (ORCID: https://orcid.org/0009-0001-9413-9147)
- Min Lin
- Qingze Zeng
- Yanxing Chen (ORCID: https://orcid.org/0000-0002-8571-2802)
- P. Huang (ORCID: https://orcid.org/0009-0004-1191-4139)
- Jianzhong Sun (ORCID: https://orcid.org/0000-0002-1720-9850)
- Hui Hong (ORCID: https://orcid.org/0000-0002-7238-1709)
- Xiao Luo
- Ruiting Zhang
- Shuyue Wang
- Yao Zhang
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71022
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- National Natural Science Foundation of China
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- University of California, San Diego
- Canadian Institutes of Health Research
- Natural Science Foundation of Zhejiang Province