Increased glymphatic fluid volume in untreated obstructive sleep apnea

These findings underscore the impact of OSA on the brain's glymphatic system, highlighting glymphatic dysfunction as a potential contributor to the downstream effect of untreated OSA. Comparative findings of EPC and pCSF suggest that pCSF may be a more sensitive approach to evaluating sublet changes in glymphatic fluid burden. Further research is necessary to substantiate these findings in a longitudinal within-subject cohort before and after CPAP treatment.