A Novel Brain‐Penetrable Nanocarrier Delivers Brain‐derived Neurotrophic Factor for Treatment of Alzheimer’s Disease
Our findings suggest BDNF-TPN is a promising treatment for reducing neuroinflammation, apoptosis and programmed cell death in AD mouse brains, while improving synaptic plasticity and cognitive function. Reference 1. Zhang W, et al. Sig Transduct Target Ther 2023, 8, 267. 2. He C, et al. Nano Today. 2020;35:100965. 3. Park E, et al. Advanced Science. 2023, 10(12):2207238. 4. Park E, et al. Biomaterials. 2025 Jan 24:123142.
Authors
- Lily Yi Li (ORCID: https://orcid.org/0000-0002-1666-9556)
- Jeffrey T. Henderson (ORCID: https://orcid.org/0000-0001-7636-2604)
- Paul E. Fraser (ORCID: https://orcid.org/0000-0003-1227-4239)
- Elliya Park
- Andrew M. Rauth (ORCID: https://orcid.org/0000-0002-7551-2540)
- Chunsheng He
- Taksim Ahmed
- Xiao Yu Wu
- Azhar Z. Abbasi
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_103999
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00