Associations between CSF complement factors and biomarkers of amyloid, tau, neurofilament light chain, and α‐synuclein in AD, DLB, and PD
CSF complement factors were associated with amyloid, tau, NfL, and α-synuclein, suggesting complement system involvement in several neurodegenerative diseases. Complement showed disease-specific associations with amyloid in AD and α-synuclein in PD.
Authors
- K. Blennow
- Marianne Wettergreen
- Kathrin Brockmann (ORCID: https://orcid.org/0000-0002-7515-8596)
- Sandra Kuhs (ORCID: https://orcid.org/0000-0003-0464-7031)
- Olga Borejko (ORCID: https://orcid.org/0000-0003-0487-586X)
- A Spottke
- Marianna Rizzo (ORCID: https://orcid.org/0000-0002-8165-7367)
- Rajaraman Krishnan (ORCID: https://orcid.org/0000-0002-5189-4097)
- van der Flier Wm
- Claire Chevalier (ORCID: https://orcid.org/0000-0003-0902-0756)
- S. Jasmijn Vos (ORCID: https://orcid.org/0000-0003-3102-514X)
- Rejko Krüger
- Betty M. Tijms
- Davit Chokoshvili
- Sara B. Gomes Fernandes
- Tormod Fladby
- Thomas Gasser
- Emrah Düzel
- Afina W. Lemstra
- Frank Jessen
- Günter U Höglinger
- Pieter Jelle Visser
- Henrik Zetterberg
- Charlotte E. Teunissen
- Gwendlyn Kollmorgen
- Giovanni B. Frisoni
- Dag Aarsland
- Frederic Brosseron
- Gabor C Petzold
Institutions
- University of Geneva (CH)
- University of Bonn (DE)
- University of Wisconsin–Madison (US)
- Centre Hospitalier de Luxembourg (LU)
- University of Cologne (DE)
- King's College London (GB)
- University of Oslo (NO)
- University of Luxembourg (LU)
- University Hospital Bonn (DE)
- Stavanger University Hospital (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- German Center for Neurodegenerative Diseases (DE)
- Karolinska Institutet (SE)
- LMU Klinikum (DE)
- Maastricht University (NL)
- Roche Pharma AG (Germany) (DE)
- Luxembourg Institute of Health (LU)
- Amsterdam Neuroscience (NL)
- Sanofi (United States) (US)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Amsterdam University Medical Centers (NL)
- Arbed (Luxembourg) (LU)
- University College London (GB)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104363
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00