Deficiency of <scp> <i>AP1M2</i> </scp> Causes a New Autoinflammatory Disease With Colitis
This study identifies the deficiency of AP1M2 as the cause of a new autoinflammatory disease with colitis and highlights the critical function of AP-1 in suppressing NF-κB activation and chemokine production.
Authors
- Michelle Morrow (ORCID: https://orcid.org/0000-0002-4565-2008)
- D. Kastner
- Rachel Eisenberg
- Jiahui Zhang (ORCID: https://orcid.org/0000-0002-8287-6991)
- Lindsay Henderson (ORCID: https://orcid.org/0000-0001-5516-1731)
- P. Y. Lee
- Natalie Deuitch (ORCID: https://orcid.org/0000-0002-0146-1162)
- Yusha Wang (ORCID: https://orcid.org/0000-0002-6507-5658)
- Taijie Jin
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Katrina Allis
- Jialin Dai
- Renkui Bai
- Chenlu Liu
- Wei Yin
- Qing Zhou
Institutions
- Boston Children's Hospital (US)
- Albert Einstein College of Medicine (US)
- Shaare Zedek Medical Center (IL)
- Sir Run Run Shaw Hospital (CN)
- National Human Genome Research Institute (US)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1002/art.70038
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhejiang University
- National Key Research and Development Program of China