Neuropsychiatric symptom subtypes associated with Alzheimer's disease and related dementia neuropathologic changes in the National Alzheimer's Coordinating Center neuropathology cohort
We found that timing of symptom onset and specific symptom cluster had distinct patterns of association with neuropathologic lesions, and that these may differ according to the presence and severity of concurrent ADNC. Additionally, we report that NPS increased significantly with the number of neuropathologic changes present, providing support for reducing total neuropathologic burden, perhaps through lifestyle modification and disease-modifying treatments, as a method for harm-reduction in dementia.
Authors
- Michael Cuccaro
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Alyssa N. De Vito (ORCID: https://orcid.org/0000-0002-4078-3869)
- Walter W. Kukull
- Brenna Cholerton
- Thomas J. Montine
Institutions
- University of Miami (US)
- University of Washington (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106793
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00