Cortical asymmetry index in Autosomal Dominant Alzheimer's Disease: insights from the Clínic Barcelona and DIAN cohorts over time
ADAD individuals show increased brain asymmetry as the disease progresses and correlate with key biomarkers in both cohorts. APOE3/3 showed higher levels of asymmetry than the other APOE genotypes. Longitudinally, CAI increases significantly in SMC and SMC-AD, highlighting its potential as a marker for disease monitoring. These findings highlight CAI's potential as a tool for early detection and tracking of AD progression.
Authors
- Agnès Pérez‐Millan (ORCID: https://orcid.org/0000-0002-3006-9792)
- Núria Guillén (ORCID: https://orcid.org/0000-0002-1341-9834)
- Adrià Tort‐Merino (ORCID: https://orcid.org/0000-0002-5646-0482)
- Beatriz Bosch‐Capdevila
- Guadalupe Fernández‐Villullas (ORCID: https://orcid.org/0000-0002-0569-1344)
- Neus Falgàs Martínez
- Mircea Balasa
- Sergi Borrego‐Écija
- Anna Antonell
- Albert Lladó
- Raquel Sánchez‐Valle
- The Dominantly Inherited Alzheimer Network (DIAN)
Institutions
- Universitat Oberta de Catalunya (ES)
- Hospital Clínic de Barcelona (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103242
- Primary Topic
- Hemispheric Asymmetry in Neuroscience
- Type
- article
- Field-Weighted Citation Impact
- 0.00