285P Endogenous retrovirus are shared cancer stem-cell and senescent cell antigens suitable for immunotherapeutic targeting

Cellular senescence is an important driver of cancer development and progression. Endogenous retrovirus (ERVs), remnants of ancient viral infections persists as thousands of partially degraded proviral sequences. ERVs are widely expressed in human and mouse cancer and HERV-K loci of the HML-2 family are known to be reactivated in senescence and cancer. In senescent cells HERV-K reinforces senescence and inflammation, while in cancer cells it supports cell survival, proliferation and invasiveness.

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Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101484
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
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article

285P Endogenous retrovirus are shared cancer stem-cell and senescent cell antigens suitable for immunotherapeutic targeting

KV Grunddal, AV Bermejo, PJ Holst, L. Neukirch et al.
Immuno-Oncology Technology
Telomeres, Telomerase, and Senescence
article

285P Endogenous retrovirus are shared cancer stem-cell and senescent cell antigens suitable for immunotherapeutic targeting

KV Grunddal, AV Bermejo, PJ Holst, L. Neukirch, M. Perez-Penco, S. Mariya, L. Duvnjak, A-M.C. Andersson, M.D. Müller, I.S. Pedersen, S. Schroedel, H. Darusman, C. Thirion
article en

Abstract

Cellular senescence is an important driver of cancer development and progression. Endogenous retrovirus (ERVs), remnants of ancient viral infections persists as thousands of partially degraded proviral sequences. ERVs are widely expressed in human and mouse cancer and HERV-K loci of the HML-2 family are known to be reactivated in senescence and cancer. In senescent cells HERV-K reinforces senescence and inflammation, while in cancer cells it supports cell survival, proliferation and invasiveness.

Immuno-Oncology TechnologyVol. 28
University of Copenhagen (DK), IPB University (ID), Frederiksberg Hospital (DK), Herlev Hospital (DK), Toptica Photonics (Germany) (DE)
Openalex Percentile: Top 33%
Telomeres, Telomerase, and Senescence
DOIOpen Access PDFOpenAlex
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285P Endogenous retrovirus are shared cancer stem-cell and senescent cell antigens suitable for immunotherapeutic targeting — KV Grunddal, AV Bermejo, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS