Predictive Factors for Gastrointestinal and Hepatic Adverse Events During 5‐Aminolevulinic Acid–Guided Photodynamic Diagnosis in Bladder Cancer: Exploratory Analysis of the Phase <scp>III SPP2C102</scp> Trial
5-ALA-related nausea, vomiting, and transient liver-enzyme elevations were common but generally mild. Simple bedside variables-particularly sex and blood pressure-may guide selective antiemetic prophylaxis and closer biochemical monitoring in routine practice.
Authors
- Yoshinobu Komai (ORCID: https://orcid.org/0000-0003-0353-9303)
- Kiyohide Fujimoto (ORCID: https://orcid.org/0000-0003-1507-2464)
- Toyonori Tsuzuki (ORCID: https://orcid.org/0000-0002-4855-4366)
- Ryo Fujiwara (ORCID: https://orcid.org/0000-0001-6566-1430)
- Rikiya Taoka
- Keita Kobayashi (ORCID: https://orcid.org/0000-0001-9279-3156)
- Atsushi Ikeda (ORCID: https://orcid.org/0000-0003-0934-5470)
- M. Sugimoto
- Makito Miyake
- Hideo Fukuhara
- Kent Kanao
- Yusuke Sato
- Mototsugu Oya
- Keiji Inoue
Institutions
- University of Kochi (JP)
- Kochi Medical School Hospital (JP)
- Aichi Medical University Hospital (JP)
- Keio University Hospital (JP)
- University of Tokyo Hospital (JP)
- Nara Medical University Hospital (JP)
- University of Tsukuba Hospital (JP)
- Yamaguchi University Hospital (JP)
- Saitama International Medical Center (JP)
- Kagawa University Hospital (JP)
- Japanese Foundation For Cancer Research (JP)
- Kōchi University (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- International Journal of Urology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1111/iju.70328
- Citations
- 1
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.52