Deciphering Dyslexia Phenotypes in Chinese Language Users with Primary Progressive Aphasia
Contrary to English svPPA patients who primarily struggled with irregular word reading and frequently exhibit surface dyslexia, Chinese PPA patients showed no variant-specific differences across lexicality, and svPPA-specific over-regularization phenomenon were found at the lexical (i.e., heteronym-reading) and not sub-lexical reading. These findings underscore that diagnostic criteria for PPA syndromes should be linguistically tailored to accommodate language topology effect.
Authors
- Pei‐Ning Wang (ORCID: https://orcid.org/0000-0001-9902-1386)
- YiChen Lee (ORCID: https://orcid.org/0009-0004-8293-4786)
- Joshua Tsoh (ORCID: https://orcid.org/0000-0001-9001-5158)
- Yu‐Ruei Lin
- Raymond Y. Lo (ORCID: https://orcid.org/0000-0001-6510-1935)
- Isabel Elaine Allen (ORCID: https://orcid.org/0000-0001-9029-9744)
- Fangda Leng
- Maria Luisa Gorno Tempini
- Yu Sun
- Adrian Wong
- Ta‐Fu Chen
- Maria Luisa Mandelli
- Lung‐Tat Chan
- Chien Jung Lu
- Lorinda Li‐Ying Kwan Chen
- Boon Lead Tee
- YuChen Chuang
Institutions
- Chinese University of Hong Kong (HK)
- University of California, San Francisco (US)
- Shatin Hospital (CN)
- Taipei Veterans General Hospital (TW)
- National Dong Hwa University (TW)
- Education University of Hong Kong (HK)
- En Chu Kong Hospital (TW)
- University Memory and Aging Center (US)
- Prince of Wales Hospital (CN)
- National Taiwan University Hospital (TW)
- National Hsinchu University of Education (TW)
- Global Brain Health Institute (US)
- Queen Elizabeth Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106949
- Primary Topic
- Neurobiology of Language and Bilingualism
- Type
- article
- Field-Weighted Citation Impact
- 0.00