Mild Behavioral Impairment affects association between centiloid concentration and cognitive trajectory
Our findings provide preliminary support for the notion that MBI affects the relationship between specific disease biomarkers and cognitive decline, with evidence of this in our centiloid results. Centiloid concentration, a standardized measure of beta amyloid-PET, may represent a particularly sensitive marker of early, stable brain changes associated with MBI in this racially diverse cohort.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Barbara L. Fischer
- Diane C. Gooding (ORCID: https://orcid.org/0000-0002-0498-9472)
- Mary F. Wyman (ORCID: https://orcid.org/0000-0001-5371-9105)
- Derek Norton
- Shenikqua Bouges (ORCID: https://orcid.org/0000-0002-4452-0548)
- Gilda E. Ennis (ORCID: https://orcid.org/0000-0003-4329-0215)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Henry Gilreath Stephenson
- Megan L. Zuelsdorff
- Carol A. Van Hulle
- Lauren W. Y. McLester‐Davis
- Carey E. Gleason
Institutions
- Alzheimer's Association (US)
- University of Wisconsin–Madison (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Geriatric Research Education and Clinical Center (US)
- University of Wisconsin Health (US)
- William S. Middleton Memorial Veterans Hospital (US)
- Wisconsin Division of Public Health (US)
- Memorial Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_106597
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00