304eP Integrative transcriptomic profiling of tumor antigens and immune genes in pancreatic cancer for rational ADCDesign

Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy with poor overall survival. Identifying tumor-associated antigens (TAAs) is essential for developing antibody-drug conjugates (ADCs) and bispecific therapies. Their combination with immune checkpoint inhibitors (ICIs) may improve clinical outcomes. We conducted transcriptomic co-expression analysis of TAAs and immune-related genes (IEGs) in PAAD, including both suppressive and activating markers.

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Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101503
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
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article

304eP Integrative transcriptomic profiling of tumor antigens and immune genes in pancreatic cancer for rational ADCDesign

B.G. Diez, A.G. Escudero, M. Amann Arévalo, M. Granja Ortega et al.
Immuno-Oncology Technology
Cancer Immunotherapy and Biomarkers
article

304eP Integrative transcriptomic profiling of tumor antigens and immune genes in pancreatic cancer for rational ADCDesign

B.G. Diez, A.G. Escudero, M. Amann Arévalo, M. Granja Ortega, J. Sastre Valera, A. Ocaña, M. García Gómez, P. Pérez Segura, S. Repáraz Herrero, M. Vizcaino Escoto, B. García Paredes, J. Bartolomé Arcilla, I. Moreno, A. Cabello Izquierdo
article en

Abstract

Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy with poor overall survival. Identifying tumor-associated antigens (TAAs) is essential for developing antibody-drug conjugates (ADCs) and bispecific therapies. Their combination with immune checkpoint inhibitors (ICIs) may improve clinical outcomes. We conducted transcriptomic co-expression analysis of TAAs and immune-related genes (IEGs) in PAAD, including both suppressive and activating markers.

Immuno-Oncology TechnologyVol. 28
No poverty
Openalex Percentile: Top 30%
Cancer Immunotherapy and Biomarkers
DOIOpen Access PDFOpenAlex
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