Hypoxic TCs-preconditioned MSCs ameliorate acute lung injury via enhanced Treg recruitment and function through CXCL5/6-CXCR1 axis
These findings reveal a novel mechanism by which hypoxic TC supernatant enhances MSC therapeutic efficacy in ALI through the CXCL5/6-CXCR1 axis, providing a promising strategy for optimizing cellular therapy in inflammatory pulmonary disorders.
Authors
- Pinwen Wu
- L. Yin (ORCID: https://orcid.org/0000-0001-9003-6012)
- Rongrong Gao (ORCID: https://orcid.org/0000-0002-3990-5910)
- Youwei Zhu
- Ye Zhou (ORCID: https://orcid.org/0009-0007-0545-6874)
- Huihui Ju
- Hao Fang
- Xu Yeyang Zhang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Shanghai Medical Information Center (CN)
- Shanghai Public Health Clinical Center (CN)
- Zhongshan Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s13287-025-04858-6
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63