Cognitive Reserve is Associated with Entorhinal Cortex Tau Burden in an Older, Cognitively Unimpaired Clinical Trial Cohort (U.S. POINTER)
In the U.S.POINTER Cohort, higher CR predicted lower tau burden in the ERC, a brain area first affected by tau deposition. Meta-ROI tau may be too low in this cognitively unimpaired sample to reveal associations. The findings suggest a possible role of CR in conferring biological resistance to AD pathology.
Authors
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Christopher J. Weber
- Michelle M. York
- Valory Pavlik (ORCID: https://orcid.org/0000-0003-4376-3756)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Thomas Holland (ORCID: https://orcid.org/0000-0002-9888-0194)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Melissa Yu
- Susan M. Landau
- Laura Lovato
- Rachel A. Whitmer
Institutions
- Alzheimer's Association (US)
- Houston Methodist (US)
- Baylor College of Medicine (US)
- Wake Forest University (US)
- Rush University (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104493
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00