Xijiaqi Formula attenuates myocardial infarction-induced chronic heart failure by inhibiting TGF-β1/Smads-mediated fibroblast activation
XJQ significantly attenuated the progression from MI to CHF by inhibiting fibroblast activation mediated by TGF-β1/Smads signaling. The molecular mechanisms underlying this effect appear to be intricately linked to its regulation of ECM remodeling proteins, specifically <i>Adamts2</i>, <i>Itgbl1</i>, <i>Fbln1</i>, and <i>Ltbp3</i>.
Authors
- Yu-zhuo Wu
- Xiao-Hong Wei (ORCID: https://orcid.org/0000-0001-5327-6279)
- Hong-Cai Shang
- Huan Xia
- Qian Zhang
- Sheng Lin
- Lin-Nan Zhou
- Gui-Yang Xia
- Xue-Fen Wu
- Jie Chen
- Wan-Ting Li
Institutions
- Beijing University of Chinese Medicine (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1080/13880209.2025.2602234
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39