Subjective Visuospatial Decline in Cognitively Unimpaired Individuals

A subset of CU individuals endorsed subjective visuospatial decline, a cognitive domain that does not typically decline in healthy aging. The positive relationships observed between subjective visuospatial decline and biomarkers of amyloid and tau suggest that the ECOG can be a useful tool in capturing subtle visuospatial decline in addition to early memory concerns in preclinical AD. Developing methodology to predict the development of atypical AD variants has significant implications for optimizing early diagnosis and treatment of this disease.