A new aromadendrane sesquiterpene from the liana Alafia erythrophthalma

A new aromadendrane sesquiterpene derivative, (alafinol, 1 ), alongside with fourteen known compounds were isolated from the methanolic extract of the liana of Alafia erythrophthalma (K. Schum.) Leeuwenb. The structures of the compounds were determined by analyses of spectroscopic (1D and 2D NMR, HRMS) data and circular dichroism spectra as well as by comparison with literature records. Compounds 5 , 8–12 and 14 are reported here for the first time from the genus Alafia. Compounds 1–2 and crude extract were tested for their antimicrobial activity against the bacterial strains Staphylococcus aureus, Salmonella typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and the fungal strains Candida albicans and Cryptococcus neoformans . The crude extract exhibited weak activity against Pseudomonas aeruginosa with a MIC value of 312.5 μg/mL. • One new natural product alafinol (1) and fourteen known (2–15) were isolated from liana of Alafia erythrophthalma. • The absolute configuration of alafinol ( 1 ) was determined. • Six known triterpenes and stigmasterol-3-O-β-D-glucopyranoside are reported here for the first time from the genus Alafia. • The structures of all compounds were elucidated by 1D and 2D NMR spectroscopy. • The crude extract showed weak activity against Pseudomonas aeruginosa with a MIC value of 312.5 μg/mL.