Differential performance of plasma <i>p</i> ‐tau217 in detecting intermediate vs high Alzheimer's disease neuropathologic change
Plasma p-tau217 markers effectively classify ADNC extremes but are less reliable for accurately assessing low/intermediate ADNC levels, reflecting their limited utility for biological disease staging. This weaker performance in preclinical cases, including failure to reliably identify A+T- cases as positive, challenges their potential role in early AD detection. Complementary imaging may be needed to improve reliability in early stages.
Authors
- Michel J. Grothe (ORCID: https://orcid.org/0000-0003-2600-9022)
- Andrés Perissinotti (ORCID: https://orcid.org/0000-0003-4190-2425)
- Valentina Garibotto (ORCID: https://orcid.org/0000-0003-2422-698X)
- Ismini Mainta (ORCID: https://orcid.org/0000-0001-5296-0116)
- Alexis Moscoso (ORCID: https://orcid.org/0000-0003-0170-036X)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Martijn van Essen (ORCID: https://orcid.org/0000-0002-2257-1651)
- Stamatia Karagianni (ORCID: https://orcid.org/0009-0006-2505-770X)
- Omar Rodríguez‐Fonseca
- Valle Camacho
Institutions
- University of Geneva (CH)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- University Hospital of Geneva (CH)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- UK Dementia Research Institute (GB)
- Centre d'Imagerie BioMedicale (CH)
- Hospital Universitario Lucus Augusti (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Fundacion Centro De Investigacion De Enfermedades Neurologicas (ES)
- University College London (GB)
- Universitat de Barcelona (ES)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104257
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00