White Matter and Tau Pathology: Evidence for Propagation and Deterioration
Our work sheds light on the mechanistic role of intact WM in tau accumulation (through dense microtubules and synaptic connections) and the deterioration of WM that is associated with higher rates of tau accumulation. We found interesting sex differences that warrant further investigation.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- R. Petersen
- Jonathan Graff‐Radford
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Jianqiao Tian (ORCID: https://orcid.org/0000-0002-3994-2922)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Sheelakumari Raghavan
- Christopher G Schwarz
- David S. Knopman
- Kejal Kantarci
- Robert I. Reid
- Clifford R. Jack
- Prashanthi Vemuri
Institutions
- Nanjing Drum Tower Hospital (CN)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103781
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00