Latent Cognitive Trajectories in Late Life: An Exploratory Analysis
While multiple subgroups move from cognitively normal to dementia, our latent class approach highlights subtypes that decline at different times and at different rates. Future work will seek to integrate disease time into models, clarify the stability of the observed subgroups of decliners, and characterize the neuropathological and neuroimaging features that contribute to the distinct etiologies of decline across domains.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Michelle Clifton
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- M. Carmen Ruiz Gómez
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Phoebe Scollard
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- F. S. Turner (ORCID: https://orcid.org/0000-0002-7935-7621)
- Jo Ellen Wilson (ORCID: https://orcid.org/0000-0003-2565-8012)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Alaina Durant
- Dandan Liu (ORCID: https://orcid.org/0000-0002-7176-8346)
- Lisa Laverne Barnes
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Andrew Joel Saykin
- Katherine A. Gifford (ORCID: https://orcid.org/0000-0001-6232-9408)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- Aditi Sathe
- Kwangsik Nho
- Mary Ellen I. Koran
- Marilyn S. S. Albert
- Miguel Arce Rentería
- Walter W. Kukull
- Jane Zyski
- Adam Brickman
- Susan M. Resnick
- Jason J. Hassenstab
- Carlos Cruchaga
- Jennifer J. Manly
- Angela L. Jefferson
- Paul K Crane
- Shubhabrata Mukherjee
- Yang An
- Badri N. Vardarajan
- Richard Mayeux
- Arthur W. Toga
- C. Dirk Keene
- Eric B Larson
- Jesse Mez
- Lori L Beason‐Held
- David A. A. Bennett
- Julie A Schneider
- Luigi Ferrucci
- Michael L. Lee
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- VA Tennessee Valley Healthcare System (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Dr. John T. Macdonald Foundation (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105147
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00