Single‐cell digital twins identify drug targets and repurposable medicine in Alzheimer’s disease
In summary, we demonstrated a single-cell digital twin framework for cell type-specific target identification and drug repurposing in AD and other AD-related dementia if broadly applied.
Authors
- Yunxiao Ren (ORCID: https://orcid.org/0000-0002-0076-0857)
- Andrew A. Pieper
- Jeffrey L. Cummings
- Feixiong Cheng
Institutions
- Cleveland Clinic (US)
- University of Nevada, Las Vegas (US)
- University Hospitals of Cleveland (US)
- Cleveland Clinic Lerner College of Medicine (US)
- University Hospitals Cleveland Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_102982
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00