The role of reserve in cognitive and motor function and responsivity to multi‐domain interventions for Mild Cognitive Impairment – Results from the SYNERGIC Study
This far, MR predicted baseline cognitive and motor performance. LME will reveal whether MR and CR will impact responsivity to intervention. This far, we conclude that MR may be more sensitive in detecting baseline cognitive and motor benefits. The completed study will illuminate the distinct benefits of CR and MR on intervention efficacy and the relevance of personalized interventions for MCI.
Authors
- Laura Elizabeth Middleton (ORCID: https://orcid.org/0000-0001-8624-3123)
- Richard Camicioli (ORCID: https://orcid.org/0000-0003-2977-8660)
- Karen Li (ORCID: https://orcid.org/0000-0002-0261-743X)
- Teresa Liu‐Ambrose
- Quincy J Almeida
- Manuel Montero‐Odasso
- Eden Mancor
- Louis Bherer
Institutions
- Western University (CA)
- University of British Columbia (CA)
- University of Waterloo (CA)
- University of Alberta (CA)
- Parkwood Institute (CA)
- CARE Canada (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Research Institute for Aging (CA)
- Concordia University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70858_102295
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00