Sex‐specific genetic predictors of hippocampal volume in older adults
We extend findings of a previously reported AD risk variant near SHARPIN to hippocampal volume and provide evidence of novel sex-specific genetic effects. While replication is warranted, our results suggest the importance of genetic predictors and sex differences on imaging biomarkers.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Niranjana Shashikumar
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Skylar Walters
- Mohamad J. Alshikho
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Qiongshi Lu (ORCID: https://orcid.org/0000-0002-4514-0969)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-7176-8346)
- Lisa Laverne Barnes
- Andrew Joel Saykin
- Kwangsik Nho
- Mary Ellen I. Koran
- Marilyn S. S. Albert
- Walter W. Kukull
- Adam Brickman
- Susan M. Resnick
- Di Wang
- Philip L. De Jager
- Toshiko Tanaka
- Lori L Beason‐Held
- Guray Erus
- Angela L. Jefferson
- Yang An
- Mohamad Habes
- Jason M Fletcher
- L. Taylor Davis
- Reisa A. Sperling
- David A. A. Bennett
- The Alzheimer's Disease Neuroimaging Initiative (ADNI); The Alzheimer's Disease Sequencing Project (ADSP)
- Jie Song
- Julie A Schneider
- Shannon L Risacher
Institutions
- Rush University Medical Center (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Vanderbilt University (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Massachusetts General Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Institute for Neurodegenerative Disorders (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104200
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00