Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1
<sup>18</sup>F-SMBT-1 is a robust surrogate marker of regional reactive astrogliosis. It is highly correlated with Aβ burden and with plasma GFAP. High <sup>18</sup>F-SMBT-1 precedes and predicts high Aβ suggesting reactive astrogliosis is an interesting target for early therapeutic interventions.
Authors
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103477
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00