137P Intra-tumoral recombinant human adenovirus type 5 (H101) in persistent/recurrent/metastatic cervical cancer: Efficacy, safety, and mechanisms via spatial transcriptomics

Prospective, large-scale validation in cervical cancer and its mechanism on the tumor immune microenvironment (TIME) are yet to be achieved. This study aims to evaluate the efficacy and safety of H101 in cervical cancer and to explore its effects on the TIME via Xenium in situ spatial transcriptomics.

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Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101221
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
0.00
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article

137P Intra-tumoral recombinant human adenovirus type 5 (H101) in persistent/recurrent/metastatic cervical cancer: Efficacy, safety, and mechanisms via spatial transcriptomics

T. Wang, J. Wang, Z. Liu, J. Su et al.
Immuno-Oncology Technology
Virus-based gene therapy research
article

137P Intra-tumoral recombinant human adenovirus type 5 (H101) in persistent/recurrent/metastatic cervical cancer: Efficacy, safety, and mechanisms via spatial transcriptomics

T. Wang, J. Wang, Z. Liu, J. Su, F. Wang, J. Zhang, F. Shi, Q. Zhang
article en

Abstract

Prospective, large-scale validation in cervical cancer and its mechanism on the tumor immune microenvironment (TIME) are yet to be achieved. This study aims to evaluate the efficacy and safety of H101 in cervical cancer and to explore its effects on the TIME via Xenium in situ spatial transcriptomics.

Immuno-Oncology TechnologyVol. 28
Zunyi Medical University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Liupanshui Normal University (CN), Affiliated Hospital of Zunyi Medical College (CN), Xi'an Jiaotong University (CN)
Good health and well-being
Openalex Percentile: Top 25%
Virus-based gene therapy research
DOIOpen Access PDFOpenAlex
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137P Intra-tumoral recombinant human adenovirus type 5 (H101) in persistent/recurrent/metastatic cervical cancer: Efficacy, safety, and mechanisms via spatial transcriptomics — T. Wang, J. Wang, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS