Astrocyte and Glial interaction in developing novel therapeutic strategies
We show that neuroinflammation and cell death pathways are important drivers of disease progression in preclinical and early AD. We propose that Aβ initiates a vicious cycle of neuroinflammation, glia activation, neuronal dysfunction and activation of cell death pathways that underlines the need for immunomodulatory interventions already in the early AD disease phase.
Authors
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Nesrine Rahmouni
- Marcel S. Woo (ORCID: https://orcid.org/0000-0002-1306-2708)
- Gassan Massarweh (ORCID: https://orcid.org/0000-0003-2259-9627)
- Jaime Fernández Arias (ORCID: https://orcid.org/0000-0002-6810-5920)
- Arthur C. Macedo (ORCID: https://orcid.org/0000-0002-3957-0284)
- Tevy Chan (ORCID: https://orcid.org/0009-0001-9134-5949)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Robert Hopewell (ORCID: https://orcid.org/0000-0002-2478-5872)
- Kaj Blennow
- Yansheng Zheng
- Yi‐Ting Wang
- Cécile Tissot (ORCID: https://orcid.org/0000-0002-5022-2213)
- Jenna Stevenson (ORCID: https://orcid.org/0000-0003-2848-1451)
- Lydia Trudel (ORCID: https://orcid.org/0009-0002-5593-7717)
- Kely Monica Quispialaya Socualaya
- Marina P Gonçalves
- Jean‐Paul Soucy
- Henrik Zetterberg
- Andrea Benedet
- Etienne Aumont
- Joseph Therriault
- Serge Gauthier
- Seyyed Ali Hosseini
- Stijn Servaes
- Gleb Bezgin
- Paolo Vitali
- Brandon J Hall
- Pedro Rosa‐Neto
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Lawrence Berkeley National Laboratory (US)
- Universität Hamburg (DE)
- University of Pittsburgh (US)
- McGill University Health Centre (CA)
- Profu (Sweden) (SE)
- University Medical Center Hamburg-Eppendorf (DE)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103468
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00