Investigating the effects of brain and cardiovascular health on white matter microstructural properties: a comparison of stable and converting normal appearing white matter
Previously demonstrated associations with poorer WMMS (age, midlife cardiovascular risk factors, WMHV and Aβ)<sup>2</sup> were not driven solely by NAWM on the verge of becoming WMH. However, stronger effects observed in converting NAWM suggest higher midlife BP, poorer WMMS and WMH development are part of a continuous, related process, particularly in men. The similar effect of Aβ burden in men in the stable and unstable NAWM suggests the effects of Aβ on WMMI are not driven by tissue later converting to WMH.
Authors
- Heidi Murray‐Smith (ORCID: https://orcid.org/0000-0002-1313-7263)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- William Coath (ORCID: https://orcid.org/0000-0002-3976-9461)
- Jo Barnes
- Frederik Barkhof
- Sarah‐Naomi James
- Jennifer M Nicholas
- Thomas M. Brown
- Jonathan M Schott
- Ian B. Malone
Institutions
- King's College London (GB)
- Hawassa University (ET)
- London School of Hygiene & Tropical Medicine (GB)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- Medical Research Council (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104402
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00