Bone marrow mesenchymal stem cell-derived circHECTD1 targets claudin1 through the CTCF/METTL3 axis to alleviate ulcerative colitis
Exo-circHECTD1 inhibits METTL3 transcription by binding to CTCF to reduce claudin1 m<sup>6</sup>A modification and promote claudin1 expression, thereby regulating the balance of gut microbiota and Th17/Treg cells and alleviating UC.
Authors
- Houxiang Zhou
- F Li
- Miao Wang (ORCID: https://orcid.org/0000-0003-3903-2643)
- Kailing Wang
- Y. J. Xu
- Miao Ou-Yang
- Fan Liu
- Jing Peng
- Jiawen Deng
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1007/s00018-025-06023-x
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68