Association between periodontitis and cardiovascular mortality, all-cause mortality in patients with congestive heart failure: NHANES 2009–2014

Periodontitis is highly prevalent worldwide, but its association with cardiovascular mortality and all-cause mortality in patients with congestive heart failure (CHF) has not yet received sufficient attention. In this study, weighted logistic regression was employed to examine the relationship between periodontitis and CHF, and weighted Cox regression was used to analyze the relationship between periodontitis and all-cause mortality and cardiovascular mortality. Subgroup analyses were conducted to investigate the impact of potential factors on the associations between periodontitis and CHF, all-cause mortality, and cardiovascular mortality. Sensitivity analyses were performed to enhance the robustness of the study results. In unadjusted and adjusted models for various covariates, significant positive associations were found between periodontitis and CHF, all-cause mortality, and cardiovascular mortality, with statistical significance. In the fully adjusted Model 4, the association between periodontitis and CHF was odds ratio: 2.763 (95% confidence interval [CI]: 1.563, 4.887), with all-cause mortality, was hazard ratio: 1.202 (95% CI: 1.047, 1.380), and with cardiovascular mortality was hazard ratio: 1.529 (95% CI: 1.181, 1.980). Periodontitis raises the risk of CHF, all-cause mortality, and cardiovascular mortality. The increased risk of CHF due to periodontitis may subsequently elevate the risks of all-cause and cardiovascular mortality.