Genetic and Clinical Landscape of Chinese Frontotemporal Dementia: Dominance of <i>TBK1</i> and <i>OPTN</i> Mutations

Our study demonstrates the extensive genetic and phenotypic heterogeneity of Chinese FTD patients. MAPT, GRN, and TBK1 mutation carriers are the top three in Chinese FTD patients.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103146
Primary Topic
Amyotrophic Lateral Sclerosis Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Genetic and Clinical Landscape of Chinese Frontotemporal Dementia: Dominance of TBK1 and OPTN Mutations

Haitian Nan
Alzheimer s & Dementia
Amyotrophic Lateral Sclerosis Research
article

Genetic and Clinical Landscape of Chinese Frontotemporal Dementia: Dominance of TBK1 and OPTN Mutations

Haitian Nan
article en

Abstract

Our study demonstrates the extensive genetic and phenotypic heterogeneity of Chinese FTD patients. MAPT, GRN, and TBK1 mutation carriers are the top three in Chinese FTD patients.

Alzheimer s & DementiaVol. 21(S2)
Capital Medical University (CN)
Openalex Percentile: Top 31%
Amyotrophic Lateral Sclerosis Research
DOIOpen Access PDFOpenAlex
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Genetic and Clinical Landscape of Chinese Frontotemporal Dementia: Dominance of <i>TBK1</i> and <i>OPTN</i> Mutations — Haitian Nan · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS