Proteomics at our fingertips: Coupling remote collection devices with NULISA multiplex panels
Here, we report optimization and evaluation of capillary DPS samples with a targeted proteomic panel. Analyte recovery and correlations in DPS compared to plasma varied widely depending on the analyte. This is to be expected given the diversity of targets across the panel. Ongoing work includes evaluation in an amyloid-enriched cohort, additional optimization for detecting AD-related markers, and head-to-head evaluation of other remote sampling devices.
Authors
- Randall S. Johnson (ORCID: https://orcid.org/0000-0002-4084-6639)
- Martie Marshall
- Hanna Huber (ORCID: https://orcid.org/0009-0004-3080-6870)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Laia Montoliu‐Gaya (ORCID: https://orcid.org/0000-0001-7684-6318)
- Haley Weninger
- Monica VandenLangenberg
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Beckie Jeffers
- Elysse Keske
- Aaron Fredricks
- Cindy Jensen
- Alamar TAP team
- Nicholas J. Ashton
- Sara Rusch
- Henrik Zetterberg
Institutions
- University of Wisconsin–Madison (US)
- King's College London (GB)
- Hong Kong Science and Technology Parks Corporation (HK)
- University of Wisconsin Health (US)
- The London College (GB)
- Wisconsin Division of Public Health (US)
- Banner Alzheimer’s Institute
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102262
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00