Bumetanide in Patients with Alzheimer's Disease (BumxAD): A Phase IIa Clinical Trial

This ongoing study is funded by the Stanford Knight Initiative for Brain Resilience and IRB approved. The inclusion criteria include mild cognitive impairment or mild dementia due to AD, AD medications are planned to remain stable throughout, willingness and ability to complete all aspects of the study including assessments, neuropsychological testing, and MRI. Exclusion criteria includes clinically significant abnormalities in screening laboratory tests, chronic liver disease, renal insufficiency, poorly managed hypertension and participants taking the following concomitant medications, based on the current Prescribing Information for bumetanide: lithium, drugs with ototoxic potential, drugs with nephrotoxic potential, probenecid, and indomethacin CONCLUSION: We present the clinical trial protocol and design for a phase II trial evaluating the effect of bumetanide in AD.