Phage therapy of perinephric abscess in kidney transplantation recipients caused by drug‐resistant <i>Pseudomonas aeruginosa</i>

Perinephric abscess, a common complication after kidney transplantation, often results from drug-resistant bacterial infections and is notoriously difficult to treat. Phage therapy has emerged as a promising alternative for such resistant infections. Here, we present two cases of perinephric abscesses in kidney transplant recipients (KTRs) treated with phage therapy. Our findings highlight the need for personalized treatment plans and timely intervention with phage therapy to improve patient outcomes. Future research should focus on overcoming barriers like biofilms to make this treatment more effective. Ultimately, phage therapy could lead to better survival rates and improved quality of life for transplant patients facing severe infections. This study is a step forward in the fight against superbugs, offering a potential alternative when antibiotics fail.

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Publication Details

Journal
mLife
Published
2025-12-01
DOI
https://doi.org/10.1002/mlf2.70042
Citations
2
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
3.43

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article

Phage therapy of perinephric abscess in kidney transplantation recipients caused by drug‐resistant Pseudomonas aeruginosa

Shuguang Lu, Shuai Le, Nannan Wu, Zhuojun Zhong et al.
2 citations
mLife
Bacteriophages and microbial interactions
3.43
article

Phage therapy of perinephric abscess in kidney transplantation recipients caused by drug‐resistant Pseudomonas aeruginosa

Shuguang Lu, Shuai Le, Nannan Wu, Zhuojun Zhong, Mengyu Shen, Shiru Li, J. B. Liu, Juan Bao, Yuhao Zhu, Bo He, T. J. Zhu, Ming Li, Na Li, Mengjun Cheng, Yali Gong, Linlin Li, Jing Wang
article en
2 citations

Abstract

Perinephric abscess, a common complication after kidney transplantation, often results from drug-resistant bacterial infections and is notoriously difficult to treat. Phage therapy has emerged as a promising alternative for such resistant infections. Here, we present two cases of perinephric abscesses in kidney transplant recipients (KTRs) treated with phage therapy. Our findings highlight the need for personalized treatment plans and timely intervention with phage therapy to improve patient outcomes. Future research should focus on overcoming barriers like biofilms to make this treatment more effective. Ultimately, phage therapy could lead to better survival rates and improved quality of life for transplant patients facing severe infections. This study is a step forward in the fight against superbugs, offering a potential alternative when antibiotics fail.

mLifeVol. 4(6)
Shanghai Medical College of Fudan University (CN), Army Medical University (CN), Fudan University (CN), Shanghai CASB Biotechnology (China) (CN), Shanghai Public Health Clinical Center (CN), Zhongshan Hospital (CN), Southwest Hospital (CN), Central Hospital of Wuhan (CN), Wuhan General Hospital of Guangzhou (CN), Institute of Geographic Sciences and Natural Resources Research (CN), Chongqing Medical University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Hubei Province, National Key Research and Development Program of China
Good health and well-being
Openalex Percentile: Top 7%
Bacteriophages and microbial interactions
3.43
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