Life’s essential 8 and non-alcoholic fatty liver disease: unmasking depressive symptoms’ mediating role
This study is the first to confirm that depressive symptoms mediate the relationships between specific LE8 components and NAFLD. LE8 components are significantly correlated with NAFLD, possibly via depression-supporting a "physiological-psychological" integrated approach to NAFLD management. Targeted interventions for depressive symptoms may augment the benefits of optimized LE8 in high-risk populations.
Authors
- X Li
- Lingyan Chen
- Shan Liu (ORCID: https://orcid.org/0000-0003-1459-8923)
- Zhilong Wang
- Xuerong Luo
- Chunxia Jing
- Shuxian Zeng
Institutions
- Jinan University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s40001-025-03707-9
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00