Impact of APOE ε4 on Cognitive Progression in Individuals with Subjective Cognitive Decline: Preliminary Data from a Brazilian Cohort
Even though APOE ε4 is a well established risk factor for the development of AD, our findings suggest that the presence of this allele was not associated with significant impact on cognitive progression over a one-year period in individuals with SCD. This suggests that factors other than APOE ε4 may influence SCD trajectories, and longer follow-up studies are needed to clarify this relationship.
Authors
- Ana Letícia Amorim de Albuquerque
- Victória Tizeli Souza
- Rhaná Carolina Santos (ORCID: https://orcid.org/0000-0002-8053-1631)
- Simone Sieben da Mota
- Sarah Vitória Bristot Carnevalli
- Haniel Bispo De Souza
- Leonardo Martins de Paula
- Bárbara Loeblein Uebel (ORCID: https://orcid.org/0009-0001-9080-0399)
- Raphael Machado Castilhos
- Lucas Bastos Beltrami
- Bruno De Oliveira De Marchi
- Gabriela Raquel Paz Rivas
- Marcia L. Fagundes Chaves
- Manuella Edler Zandoná Giordani
- Eduardo R. Zimmer
- Guilherme Da Silva Carvalho
- Wyllians Vendramini Borelli
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Santa Catarina (BR)
- Instituto do Cérebro (BR)
- Hospital Moinhos de Vento (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Universidade do Vale do Rio dos Sinos (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107228
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00