Sphinganine inhibits macrophage polarization and protects against sepsis-induced intestinal injury
Sphinganine protects against sepsis-induced intestinal injury by inhibiting TLR2/NF-κB signaling, modulating macrophage polarization toward the M2 phenotype, and preserving intestinal barrier integrity.
Authors
- Zetian Wang (ORCID: https://orcid.org/0009-0004-6846-6269)
- Zhang Baiyin
- Jianguo Tang (ORCID: https://orcid.org/0000-0002-1167-7274)
- Yi-Fan Chen
- Jian Zhao
Institutions
- Shanghai Tenth People's Hospital (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-12-26
- DOI
- https://doi.org/10.3748/wjg.v31.i48.112004
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00