410P Exploratory study of chronic NLRP3 inflammasome activation in prostate cancer: Promoting cancer progression and immune escape

NLRP3 inflammasome is a key component of the innate immune response and has been shown to be expressed in cancer cells of various origins. While acute NLRP3 activation can promote anti-tumor immunity, chronic activation supports tumor progression by shaping an immunosuppressive tumor microenvironment (TME) through interleukin (IL)-1β and IL-18. However, the precise role of NLRP3 in cancer, particularly within the immune TME, remains poorly understood.

Authors

Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101407
Primary Topic
Inflammasome and immune disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

410P Exploratory study of chronic NLRP3 inflammasome activation in prostate cancer: Promoting cancer progression and immune escape

J. Bartunkova, K. Kalkusova, D. Stakheev, P. Taborska et al.
Immuno-Oncology Technology
Inflammasome and immune disorders
article

410P Exploratory study of chronic NLRP3 inflammasome activation in prostate cancer: Promoting cancer progression and immune escape

J. Bartunkova, K. Kalkusova, D. Stakheev, P. Taborska, D. Smrz
article en

Abstract

NLRP3 inflammasome is a key component of the innate immune response and has been shown to be expressed in cancer cells of various origins. While acute NLRP3 activation can promote anti-tumor immunity, chronic activation supports tumor progression by shaping an immunosuppressive tumor microenvironment (TME) through interleukin (IL)-1β and IL-18. However, the precise role of NLRP3 in cancer, particularly within the immune TME, remains poorly understood.

Immuno-Oncology TechnologyVol. 28
Good health and well-being
Openalex Percentile: Top 36%
Inflammasome and immune disorders
DOIOpen Access PDFOpenAlex
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410P Exploratory study of chronic NLRP3 inflammasome activation in prostate cancer: Promoting cancer progression and immune escape — J. Bartunkova, K. Kalkusova, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS