Efficacy of interventions to treat and prevent Alzheimer's disease in individuals with Down syndrome: A meta‐analysis and systematic review
AD interventions appear effective for individuals with DS. Pharmacological interventions, specifically donepezil, anti-depressants, EGCG, simvastatin, and nicotine, can improve a broad spectrum of AD outcomes. Exercise and cognitive training are also promising to reduce AD symptoms on this population.
Authors
- Melissa M. Pangelinan (ORCID: https://orcid.org/0000-0001-6087-2423)
- Mary Ciccarelli (ORCID: https://orcid.org/0000-0002-9086-0770)
- Emily E. Munn (ORCID: https://orcid.org/0000-0002-8434-9909)
- Viraj K. Patel
- Jill C. Fodstad (ORCID: https://orcid.org/0000-0003-4401-9304)
- Anna Montelongo
Institutions
- Indiana University Bloomington (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70858_102403
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00